ACTOS tablets are a thiazolidinedione and an agonist for peroxisome proliferator-activated receptor (PPAR) gamma that contains an oral antidiabetic medication: pioglitazone. Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. [3] It may be used with metformin, a sulfonylurea, or insulin. [3][4] Use is recommended together with exercise and diet. [4] Overview: Pioglitazone is a tablet you swallow that is used to help control your blood sugar levels if you have type 2 diabetes. ACTOS is a prescription medicine used with diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes. ACTOS is a diabetes medicine called pioglitazone hydrochloride that may be taken alone or with other diabetes medicines. Pioglitazone (Actos) is an oral medication used to treat Type 2 diabetes in adults, along with diet and exercise. It's a thiazolidinedione, which works by helping your body respond better to insulin. This medication is taken by mouth once a day and is available in both brand and generic forms. Pioglitazone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Pioglitazone is not for treating type 1 diabetes. Actos (pioglitazone) is a prescription tablet that’s used to control blood sugar levels in type 2 diabetes. Learn about side effects, dosage, uses, and more. Actos is an oral diabetes medicine that helps control blood sugar levels. Actos is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Learn about side effects, dosage, uses, what to consider, and more for Actos (pioglitazone), which is a prescription tablet that treats type 2 diabetes in adults. Actos is used to improve blood glucose management in adults with type 2 diabetes. Patients usually take Actos once a day. It may be taken with or without food. For a patient without congestive heart failure, the initial dose is usually 15 or 30 mg taken by mouth once a day.